Siquijor is the smallest island province in the Central Visayas Region. It's geographically located midway between the Visayas and Mindanao Islands. It is bounded on the Northwest by the islands of Cebu, on the Northeast by Bohol, on the East by Camiguin Island, on the South by mainland Mindanao and on the West by Negros Island. On its northern shore lays the Bohol strait, on its southeast shore, the Mindanao Sea.

Siquijor is the third smallest province in the country both in terms of population and land area, after Camiguin and Batanes.